Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets
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چکیده
منابع مشابه
Nucleus pulposus cell-matrix interactions with laminins.
The cells of the nucleus pulposus (NP) region of the intervertebral disc play a critical role in this tissue's generation and maintenance, and alterations in NP cell viability, metabolism, and phenotype with aging may be key contributors to progressive disc degeneration. Relatively little is understood about the phenotype of NP cells, including their cell-matrix interactions which may modulate ...
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Cell-based regenerative approaches have been suggested as primary or adjuvant procedures for the treatment of degenerated intervertebral disc (IVD) diseases. Our aim was to evaluate the regenerative and immunogenic properties of mildly and severely degenerated cervical nucleus pulposus (NP) cells with regard to cell isolation, proliferation and differentiation, as well as to cell surface marker...
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traumatic brain injury (tbi) results from a sudden and external physical impact to the head, and often leads to motor and cognitive impairment. using tissue engineering strategies, we aimed to review aspects of extra cellular matrix (ecm) based scaffold that could be delivered to the injured brain. the ecm is produced intracellularly and secreted to form a dense network of proteins and glycans,...
متن کاملTranscriptional profiling of the nucleus pulposus: say yes to notochord
This editorial addresses the debate concerning the origin of adult nucleus pulposus cells in the light of profiling studies by Minogue and colleagues. In their report of several marker genes that distinguish nucleus pulposus cells from other related cell types, the authors provide novel insights into the notochordal nature of the former. Together with recently published work, their work lends s...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-72859-x